Vitamin D (Cholecalciferol)
Potential for Drug-Herb Interactions
- Based on clinical evidence, there is no major risk of drug-herb interaction.
- Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of drugs such as calcipotriene, digoxin, diltiazem, thiazide diuretics and verapamil.
- Until more is known, advise patients to use vitamin D cautiously if they take medications that contains atorvastatin and CYP 3A4 Clinical research shows that taking vitamin D products significantly reduces levels of atorvastatin and its active metabolites. Some drugs metabolized by CYP 3A4 include lovastatin, clarithromycin, cyclosporine, diltiazem, estrogens, indinavir, triazolam, and others.
- Vitamin D may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.